Wnt-Responsive Cancer Stem Cells Are Located Close to Distorted Blood Vessels and Not in Hypoxic Regions in a p53-Null Mouse Model of Human Breast Cancer
Identifieur interne : 000790 ( Main/Exploration ); précédent : 000789; suivant : 000791Wnt-Responsive Cancer Stem Cells Are Located Close to Distorted Blood Vessels and Not in Hypoxic Regions in a p53-Null Mouse Model of Human Breast Cancer
Auteurs : Tegy J. Vadakkan ; John D. Landua ; Wen Bu ; Wei Wei ; Fuhai Li ; Stephen T. C. Wong ; Mary E. Dickinson ; Jeffrey M. Rosen ; Michael T. Lewis ; Mei ZhangSource :
- Stem Cells Translational Medicine [ 2157-6564 ] ; 2014.
Descripteurs français
- KwdFr :
- Adénocarcinome (), Adénocarcinome (anatomopathologie), Adénocarcinome (génétique), Animaux, Cellules souches tumorales (anatomopathologie), Cellules souches tumorales (métabolisme), Femelle, Gènes rapporteurs, Humains, Hypoxie cellulaire, Hétérogreffes, Lentivirus (génétique), Microscopie confocale, Microscopie de fluorescence multiphotonique, Protéine p53 suppresseur de tumeur (déficit), Protéine p53 suppresseur de tumeur (génétique), Protéines à fluorescence verte (biosynthèse), Protéines à fluorescence verte (génétique), Souris, Sous-unité alpha du facteur-1 induit par l'hypoxie (métabolisme), Suivi cellulaire (), Transduction génétique, Transplantation tumorale, Tumeurs du sein triple-négatives (), Tumeurs du sein triple-négatives (anatomopathologie), Tumeurs du sein triple-négatives (génétique), Tumeurs du sein triple-négatives (métabolisme), Tumeurs expérimentales de la mamelle (), Tumeurs expérimentales de la mamelle (anatomopathologie), Tumeurs expérimentales de la mamelle (génétique), Tumeurs expérimentales de la mamelle (métabolisme), Vaisseaux sanguins (anatomopathologie), Vecteurs génétiques, Voie de signalisation Wnt (génétique).
- MESH :
- anatomopathologie : Adénocarcinome, Cellules souches tumorales, Tumeurs du sein triple-négatives, Tumeurs expérimentales de la mamelle, Vaisseaux sanguins.
- biosynthèse : Protéines à fluorescence verte.
- déficit : Protéine p53 suppresseur de tumeur.
- génétique : Adénocarcinome, Lentivirus, Protéine p53 suppresseur de tumeur, Protéines à fluorescence verte, Tumeurs du sein triple-négatives, Tumeurs expérimentales de la mamelle, Voie de signalisation Wnt.
- métabolisme : Cellules souches tumorales, Sous-unité alpha du facteur-1 induit par l'hypoxie, Tumeurs du sein triple-négatives, Tumeurs expérimentales de la mamelle.
- Adénocarcinome, Animaux, Femelle, Gènes rapporteurs, Humains, Hypoxie cellulaire, Hétérogreffes, Microscopie confocale, Microscopie de fluorescence multiphotonique, Souris, Suivi cellulaire, Transduction génétique, Transplantation tumorale, Tumeurs du sein triple-négatives, Tumeurs expérimentales de la mamelle, Vecteurs génétiques.
English descriptors
- KwdEn :
- Adenocarcinoma (blood supply), Adenocarcinoma (genetics), Adenocarcinoma (pathology), Animals, Blood Vessels (pathology), Cell Hypoxia, Cell Tracking (methods), Female, Genes, Reporter, Genetic Vectors, Green Fluorescent Proteins (biosynthesis), Green Fluorescent Proteins (genetics), Heterografts, Humans, Hypoxia-Inducible Factor 1, alpha Subunit (metabolism), Lentivirus (genetics), Mammary Neoplasms, Experimental (blood supply), Mammary Neoplasms, Experimental (genetics), Mammary Neoplasms, Experimental (metabolism), Mammary Neoplasms, Experimental (pathology), Mice, Microscopy, Confocal, Microscopy, Fluorescence, Multiphoton, Neoplasm Transplantation, Neoplastic Stem Cells (metabolism), Neoplastic Stem Cells (pathology), Transduction, Genetic, Triple Negative Breast Neoplasms (blood supply), Triple Negative Breast Neoplasms (genetics), Triple Negative Breast Neoplasms (metabolism), Triple Negative Breast Neoplasms (pathology), Tumor Suppressor Protein p53 (deficiency), Tumor Suppressor Protein p53 (genetics), Wnt Signaling Pathway (genetics).
- MESH :
- chemical , biosynthesis : Green Fluorescent Proteins.
- blood supply : Adenocarcinoma, Mammary Neoplasms, Experimental, Triple Negative Breast Neoplasms.
- chemical , deficiency : Tumor Suppressor Protein p53.
- genetics : Adenocarcinoma, Green Fluorescent Proteins, Lentivirus, Mammary Neoplasms, Experimental, Triple Negative Breast Neoplasms, Tumor Suppressor Protein p53, Wnt Signaling Pathway.
- chemical , metabolism : Hypoxia-Inducible Factor 1, alpha Subunit, Mammary Neoplasms, Experimental, Neoplastic Stem Cells, Triple Negative Breast Neoplasms.
- methods : Cell Tracking.
- pathology : Adenocarcinoma, Blood Vessels, Mammary Neoplasms, Experimental, Neoplastic Stem Cells, Triple Negative Breast Neoplasms.
- Animals, Cell Hypoxia, Female, Genes, Reporter, Genetic Vectors, Heterografts, Humans, Mice, Microscopy, Confocal, Microscopy, Fluorescence, Multiphoton, Neoplasm Transplantation, Transduction, Genetic.
Abstract
High-resolution imaging techniques were used to analyze the relationship between a Wnt-responsive cancer stem cell (CSC)-enriched population and the tumor vasculature using p53-null mouse mammary tumors transduced with a Wnt signaling pathway reporter. The results demonstrate that the combined strategy of monitoring the fluorescently labeled CSCs and vasculature using high-resolution imaging techniques provides a unique opportunity to study the CSC microenvironment.
Url:
DOI: 10.5966/sctm.2013-0088
PubMed: 24797826
PubMed Central: 4073819
Affiliations:
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Wong</name></author><author><name sortKey="Dickinson, Mary E" sort="Dickinson, Mary E" uniqKey="Dickinson M" first="Mary E." last="Dickinson">Mary E. Dickinson</name></author><author><name sortKey="Rosen, Jeffrey M" sort="Rosen, Jeffrey M" uniqKey="Rosen J" first="Jeffrey M." last="Rosen">Jeffrey M. Rosen</name></author><author><name sortKey="Lewis, Michael T" sort="Lewis, Michael T" uniqKey="Lewis M" first="Michael T." last="Lewis">Michael T. 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Vadakkan</name></author><author><name sortKey="Landua, John D" sort="Landua, John D" uniqKey="Landua J" first="John D." last="Landua">John D. Landua</name></author><author><name sortKey="Bu, Wen" sort="Bu, Wen" uniqKey="Bu W" first="Wen" last="Bu">Wen Bu</name></author><author><name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name></author><author><name sortKey="Li, Fuhai" sort="Li, Fuhai" uniqKey="Li F" first="Fuhai" last="Li">Fuhai Li</name></author><author><name sortKey="Wong, Stephen T C" sort="Wong, Stephen T C" uniqKey="Wong S" first="Stephen T. C." last="Wong">Stephen T. C. Wong</name></author><author><name sortKey="Dickinson, Mary E" sort="Dickinson, Mary E" uniqKey="Dickinson M" first="Mary E." last="Dickinson">Mary E. Dickinson</name></author><author><name sortKey="Rosen, Jeffrey M" sort="Rosen, Jeffrey M" uniqKey="Rosen J" first="Jeffrey M." last="Rosen">Jeffrey M. Rosen</name></author><author><name sortKey="Lewis, Michael T" sort="Lewis, Michael T" uniqKey="Lewis M" first="Michael T." last="Lewis">Michael T. Lewis</name></author><author><name sortKey="Zhang, Mei" sort="Zhang, Mei" uniqKey="Zhang M" first="Mei" last="Zhang">Mei Zhang</name></author></analytic><series><title level="j">Stem Cells Translational Medicine</title><idno type="ISSN">2157-6564</idno><idno type="eISSN">2157-6580</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (blood supply)</term><term>Adenocarcinoma (genetics)</term><term>Adenocarcinoma (pathology)</term><term>Animals</term><term>Blood Vessels (pathology)</term><term>Cell Hypoxia</term><term>Cell Tracking (methods)</term><term>Female</term><term>Genes, Reporter</term><term>Genetic Vectors</term><term>Green Fluorescent Proteins (biosynthesis)</term><term>Green Fluorescent Proteins (genetics)</term><term>Heterografts</term><term>Humans</term><term>Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)</term><term>Lentivirus (genetics)</term><term>Mammary Neoplasms, Experimental (blood supply)</term><term>Mammary Neoplasms, Experimental (genetics)</term><term>Mammary Neoplasms, Experimental (metabolism)</term><term>Mammary Neoplasms, Experimental (pathology)</term><term>Mice</term><term>Microscopy, Confocal</term><term>Microscopy, Fluorescence, Multiphoton</term><term>Neoplasm Transplantation</term><term>Neoplastic Stem Cells (metabolism)</term><term>Neoplastic Stem Cells (pathology)</term><term>Transduction, Genetic</term><term>Triple Negative Breast Neoplasms (blood supply)</term><term>Triple Negative Breast Neoplasms (genetics)</term><term>Triple Negative Breast Neoplasms (metabolism)</term><term>Triple Negative Breast Neoplasms (pathology)</term><term>Tumor Suppressor Protein p53 (deficiency)</term><term>Tumor Suppressor Protein p53 (genetics)</term><term>Wnt Signaling Pathway (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénocarcinome ()</term><term>Adénocarcinome (anatomopathologie)</term><term>Adénocarcinome (génétique)</term><term>Animaux</term><term>Cellules souches tumorales (anatomopathologie)</term><term>Cellules souches tumorales (métabolisme)</term><term>Femelle</term><term>Gènes rapporteurs</term><term>Humains</term><term>Hypoxie cellulaire</term><term>Hétérogreffes</term><term>Lentivirus (génétique)</term><term>Microscopie confocale</term><term>Microscopie de fluorescence multiphotonique</term><term>Protéine p53 suppresseur de tumeur (déficit)</term><term>Protéine p53 suppresseur de tumeur (génétique)</term><term>Protéines à fluorescence verte (biosynthèse)</term><term>Protéines à fluorescence verte (génétique)</term><term>Souris</term><term>Sous-unité alpha du facteur-1 induit par l'hypoxie (métabolisme)</term><term>Suivi cellulaire ()</term><term>Transduction génétique</term><term>Transplantation tumorale</term><term>Tumeurs du sein triple-négatives ()</term><term>Tumeurs du sein triple-négatives (anatomopathologie)</term><term>Tumeurs du sein triple-négatives (génétique)</term><term>Tumeurs du sein triple-négatives (métabolisme)</term><term>Tumeurs expérimentales de la mamelle ()</term><term>Tumeurs expérimentales de la mamelle (anatomopathologie)</term><term>Tumeurs expérimentales de la mamelle (génétique)</term><term>Tumeurs expérimentales de la mamelle (métabolisme)</term><term>Vaisseaux sanguins (anatomopathologie)</term><term>Vecteurs génétiques</term><term>Voie de signalisation Wnt (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Green Fluorescent Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Adénocarcinome</term><term>Cellules souches tumorales</term><term>Tumeurs du sein triple-négatives</term><term>Tumeurs expérimentales de la mamelle</term><term>Vaisseaux sanguins</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Protéines à fluorescence verte</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Adenocarcinoma</term><term>Mammary Neoplasms, Experimental</term><term>Triple Negative Breast Neoplasms</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Tumor Suppressor Protein p53</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Protéine p53 suppresseur de tumeur</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term><term>Green Fluorescent Proteins</term><term>Lentivirus</term><term>Mammary Neoplasms, Experimental</term><term>Triple Negative Breast Neoplasms</term><term>Tumor Suppressor Protein p53</term><term>Wnt Signaling Pathway</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome</term><term>Lentivirus</term><term>Protéine p53 suppresseur de tumeur</term><term>Protéines à fluorescence verte</term><term>Tumeurs du sein triple-négatives</term><term>Tumeurs expérimentales de la mamelle</term><term>Voie de signalisation Wnt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hypoxia-Inducible Factor 1, alpha Subunit</term><term>Mammary Neoplasms, Experimental</term><term>Neoplastic Stem Cells</term><term>Triple Negative Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cell Tracking</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules souches tumorales</term><term>Sous-unité alpha du facteur-1 induit par l'hypoxie</term><term>Tumeurs du sein triple-négatives</term><term>Tumeurs expérimentales de la mamelle</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adenocarcinoma</term><term>Blood Vessels</term><term>Mammary Neoplasms, Experimental</term><term>Neoplastic Stem Cells</term><term>Triple Negative Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Hypoxia</term><term>Female</term><term>Genes, Reporter</term><term>Genetic Vectors</term><term>Heterografts</term><term>Humans</term><term>Mice</term><term>Microscopy, Confocal</term><term>Microscopy, Fluorescence, Multiphoton</term><term>Neoplasm Transplantation</term><term>Transduction, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adénocarcinome</term><term>Animaux</term><term>Femelle</term><term>Gènes rapporteurs</term><term>Humains</term><term>Hypoxie cellulaire</term><term>Hétérogreffes</term><term>Microscopie confocale</term><term>Microscopie de fluorescence multiphotonique</term><term>Souris</term><term>Suivi cellulaire</term><term>Transduction génétique</term><term>Transplantation tumorale</term><term>Tumeurs du sein triple-négatives</term><term>Tumeurs expérimentales de la mamelle</term><term>Vecteurs génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>High-resolution imaging techniques were used to analyze the relationship between a Wnt-responsive cancer stem cell (CSC)-enriched population and the tumor vasculature using p53-null mouse mammary tumors transduced with a Wnt signaling pathway reporter. The results demonstrate that the combined strategy of monitoring the fluorescently labeled CSCs and vasculature using high-resolution imaging techniques provides a unique opportunity to study the CSC microenvironment.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bu, Wen" sort="Bu, Wen" uniqKey="Bu W" first="Wen" last="Bu">Wen Bu</name><name sortKey="Dickinson, Mary E" sort="Dickinson, Mary E" uniqKey="Dickinson M" first="Mary E." last="Dickinson">Mary E. Dickinson</name><name sortKey="Landua, John D" sort="Landua, John D" uniqKey="Landua J" first="John D." last="Landua">John D. Landua</name><name sortKey="Lewis, Michael T" sort="Lewis, Michael T" uniqKey="Lewis M" first="Michael T." last="Lewis">Michael T. Lewis</name><name sortKey="Li, Fuhai" sort="Li, Fuhai" uniqKey="Li F" first="Fuhai" last="Li">Fuhai Li</name><name sortKey="Rosen, Jeffrey M" sort="Rosen, Jeffrey M" uniqKey="Rosen J" first="Jeffrey M." last="Rosen">Jeffrey M. Rosen</name><name sortKey="Vadakkan, Tegy J" sort="Vadakkan, Tegy J" uniqKey="Vadakkan T" first="Tegy J." last="Vadakkan">Tegy J. Vadakkan</name><name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name><name sortKey="Wong, Stephen T C" sort="Wong, Stephen T C" uniqKey="Wong S" first="Stephen T. C." last="Wong">Stephen T. C. Wong</name><name sortKey="Zhang, Mei" sort="Zhang, Mei" uniqKey="Zhang M" first="Mei" last="Zhang">Mei Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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